Why We Hate OspA: Shortest Explainer Ever

OspA is one of the outer surface proteins of the Lyme spirochete. There are many of them, labeled A, B, C, etc. So A is pretty important, being the first one. The problem with OspA is that it is a TLR2/1 agonist. Most TLR2/1 agonists are fungal, so we refer to them as fungal antigens or fungal-like antigens. Scroll down to the list, here: http://en.m.wikipedia.org/wiki/TLR2.

Fungal antigens ‘tolerize’ the immune cells, so they no longer fight off other fungal antigens. (1, 2) They can also cross-tolerize you to other types of infections. (3) The immune system becomes suppressed and multiple herpesviruses (EBV, CMV, HHV-6 to name a few) can be reactivated. (4) This is known as fungal-viral synergy. Due to the immunosuppression, you may not even produce antibodies to these herpesviruses. You also become susceptible to all kinds of opportunistic infections. The NIH refers to this model as Post Sepsis Syndrome, or “immunoparalysis.”

What do all these ongoing infections do? They screw up mitochondrial function and severely impair the red blood cells’ ability to transfer oxygen, producing fatigue. Chronic EBV is known to cause cancer, MS and other “Great Imitator” diseases.
This mechanism of fungal immunosuppression and virus reactivation is seen over and over…in contaminated vaccines (kids get the illness instead of protection), chronic mold exposure (ME/CFS/Fibro), Gulf War Illness (vaccines & MYCOplasma infection), AND magically revealed with the adverse events from the LYMErix “vaccine,” which was made with Pam3cys–the synthetic version of OspA.

If it hadn’t been intentional, we might be calling it “OopsA.”


1. Acute Hepatitis Associated With Mouse Leukemia
John B. Nelson
2. Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis.
J Immunol. 2005 Jun 1;174(11):7398-402.
Wysocka, M., Montaner, L.J., Karp, C.L.
Department of Dermatology, University of Pennsylvania, Philadelphia, 19104, USA.

Categories: Lyme 101, Lyme Disease

Tags: , , ,

16 replies

  1. Do all species of lyme spirochetes have the same properties ? Do you think the Bb was genetically engineered at PLum Island Lab or is it a naturally occurring spirochete?


  2. Your work is BRILLIANT!! I find a lot of inspiration in your writing and steal some from time to time to improve my unederstandings. Your site is also a good start for those wanna understand the ACTIONLYME.ORG sites better i think.

    Keep up the good work.

    Liked by 1 person

  3. I understand this but what can we do to help ourselves? I’m on antiviral med right now. The first week and a half, I felt great. Now, it’s the same old crap. Low grade fever, sore throat, headache, body aches, etc. thank you!!!


    • I hear you, and I’m sorry for your suffering. Until they start acknowledging that this disease is in the AIDS and cancer class, there will not be an effective treatment (unless yours happens to turn into cancer or MS and those treatments *magically* work). I wish I had a better answer. This is why we are working so hard behind the scenes to get the research fraud prosecuted. Expose the crime, reveal what the disease is, open the door to real treatments.


  4. Wonderful. Thank you for explaining things so succinctly, in a cogent manner that may be shared with those suffering without a scientific background. Keep it up.

    Liked by 1 person

  5. Fighting with you against Lyme negligence and misinformation!

    Liked by 1 person


  1. Why We Hate OspA: Shortest Explainer Ever | Slices Of Lyme Pie
  2. Lyme’s Top True Cliches
  3. Crazy, Crazy for being so Lymie
  4. Pat Smith. Really?
  5. Autoimmunity what causes it and things that may correct it. – Lee's Stuff

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: